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KMID : 0370219730170020115
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Yakhak Hoeji
1973 Volume.17 No. 2 p.115 ~ p.121
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Studies on the Synthesis of Antineoplastic Agents. VI. Synthesis and Antineoplastic Activity of 2,4-Dihydroxy-5-nitropropiophenone Derivatives
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정원근/Chung WK
이남복/Lee NB
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Abstract
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Seven beta-substituted-2, 4-dihydroxy-5-nitropropiophenones were synthesized as potential antineoplastic agents, and subjected to the screening test of survival effect and cell decrease effect. Of the synthesized compounds, beta-(1-methyl-1-hydroxymethyl) ethylamino-2,4-dihydroxy-5-nitropropiophenone, beta-(1,1-dihydroxymethyl) ethylamino-2, 4-dihydroxy-5-nitropropiophenone and beta-(1,1-dihydroxymethyl) propylamino-2,4-dihydroxy-5-nitropropiophenone were found to be active against both Ehrlich ascites carcinoma and Sarcoma 180.
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KEYWORD
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